Dr. Ryan Stone is a brilliant medical engineer on her first shuttle mission with veteran astronaut Matt Kowalsky. On a seemingly routine spacewalk, the shuttle is destroyed, leaving Stone and Kowalsky spiraling out into the blackness. The deafening silence tells them they have lost any link to Earth and any chance for rescue. As fear turns to panic, every gulp of air eats away at what little oxygen is left, and the only way home may be to go further...

A return to the world of the Road Warrior, Max Rockatansky. Haunted by his turbulent past, he believes the best way to survive is to wander alone. Nevertheless, he becomes swept up with a group fleeing across the Wasteland in a War Rig driven by an elite Imperator, Furiosa. They are escaping a Citadel tyrannized by the Immortan Joe, from whom something irreplaceable has been taken. Enraged, the Warlord with his gangs, pursues the rebels ruthlessly...