As coordinated attacks by animals against humans increase and escalate, young biologist Jackson Oz and ecologist Chloe Tousignant warn world leaders that soon there will be nowhere left for humans.

Outside a peaceful town in central Maine, a monster is waiting. Cujo is a two-hundred-pound Saint Bernard, the best friend Brett Camber has ever had. One day, Cujo chases a rabbit into a cave inhabited by sick bats and emerges as something new altogether. Meanwhile, Vic and Donna Trenton, and their young son Tad, move to Maine. They are seeking peace and quiet, but life in this small town is not what it seems. As Tad tries to fend off the terror...

All of the barnyard animals are excited about the arrival of a new duckling, until the noisy little one refuses to go to sleep.